- Antigua and Barbuda
- Antigua Naval Dockyard and Related Archaeological Sites
- Argentina
- Los Glaciares National Park #
- Jesuit Missions of the Guaranis: San Ignacio Mini, Santa Ana, Nuestra Señora de Loreto and Santa Maria Mayor (Argentina), Ruins of Sao Miguel das Missoes (Brazil) *
- Iguazu National Park
- Cueva de las Manos, Río Pinturas
- Península Valdés
- Ischigualasto / Talampaya Natural Parks
- Jesuit Block and Estancias of Córdoba
- Quebrada de Humahuaca
- Qhapaq Ñan, Andean Road System *
- The Architectural Work of Le Corbusier, an Outstanding Contribution to the Modern Movement *
- Los Alerces National Park
- ESMA Museum and Site of Memory – Former Clandestine Center of Detention, Torture and Extermination
- Barbados
- Historic Bridgetown and its Garrison
- Belize
- Belize Barrier Reef Reserve System
- Bolivia (Plurinational State of)
- City of Potosí
- Jesuit Missions of the Chiquitos
- Historic City of Sucre
- Fuerte de Samaipata
- Noel Kempff Mercado National Park
- Tiwanaku: Spiritual and Political Centre of the Tiwanaku Culture
- Qhapaq Ñan, Andean Road System *
- Brazil
- Historic Town of Ouro Preto
- Historic Centre of the Town of Olinda
- Jesuit Missions of the Guaranis: San Ignacio Mini, Santa Ana, Nuestra Señora de Loreto and Santa Maria Mayor (Argentina), Ruins of Sao Miguel das Missoes (Brazil) *
- Historic Centre of Salvador de Bahia
- Sanctuary of Bom Jesus do Congonhas
- Iguaçu National Park
- Brasilia
- Serra da Capivara National Park
- Historic Centre of São Luís
- Atlantic Forest South-East Reserves
- Discovery Coast Atlantic Forest Reserves
- Historic Centre of the Town of Diamantina
- Central Amazon Conservation Complex 33
- Pantanal Conservation Area
- Brazilian Atlantic Islands: Fernando de Noronha and Atol das Rocas Reserves
- Cerrado Protected Areas: Chapada dos Veadeiros and Emas National Parks
- Historic Centre of the Town of Goiás
- São Francisco Square in the Town of São Cristóvão
- Rio de Janeiro: Carioca Landscapes between the Mountain and the Sea
- Pampulha Modern Ensemble
- Valongo Wharf Archaeological Site
- Paraty and Ilha Grande – Culture and Biodiversity
- Sítio Roberto Burle Marx
- Chile
- Rapa Nui National Park
- Churches of Chiloé
- Historic Quarter of the Seaport City of Valparaíso
- Humberstone and Santa Laura Saltpeter Works
- Sewell Mining Town
- Qhapaq Ñan, Andean Road System *
- Settlement and Artificial Mummification of the Chinchorro Culture in the Arica and Parinacota Region
- Colombia
- Port, Fortresses and Group of Monuments, Cartagena
- Los Katíos National Park
- Historic Centre of Santa Cruz de Mompox
- National Archeological Park of Tierradentro
- San Agustín Archaeological Park
- Malpelo Fauna and Flora Sanctuary
- Coffee Cultural Landscape of Colombia
- Qhapaq Ñan, Andean Road System *
- Chiribiquete National Park – “The Maloca of the Jaguar”
- Costa Rica
- Talamanca Range-La Amistad Reserves / La Amistad National Park *
- Cocos Island National Park
- Area de Conservación Guanacaste
- Precolumbian Chiefdom Settlements with Stone Spheres of the Diquís
- Cuba
- Old Havana and its Fortification System
- Trinidad and the Valley de los Ingenios
- San Pedro de la Roca Castle, Santiago de Cuba
- Desembarco del Granma National Park
- Viñales Valley
- Archaeological Landscape of the First Coffee Plantations in the South-East of Cuba
- Alejandro de Humboldt National Park
- Urban Historic Centre of Cienfuegos
- Historic Centre of Camagüey
- Dominica
- Morne Trois Pitons National Park
- Dominican Republic
- Colonial City of Santo Domingo
- Ecuador
- City of Quito
- Galápagos Islands
- Sangay National Park #
- Historic Centre of Santa Ana de los Ríos de Cuenca
- Qhapaq Ñan, Andean Road System *
- El Salvador
- Joya de Cerén Archaeological Site
- Guatemala
- Antigua Guatemala
- Tikal National Park
- Archaeological Park and Ruins of Quirigua
- National Archaeological Park Tak’alik Ab’aj
- Haiti
- National History Park – Citadel, Sans Souci, Ramiers
- Honduras
- Maya Site of Copan
- Río Plátano Biosphere Reserve
- Jamaica
- Blue and John Crow Mountains
- Mexico
- Historic Centre of Mexico City and Xochimilco
- Historic Centre of Oaxaca and Archaeological Site of Monte Albán
- Historic Centre of Puebla
- Pre-Hispanic City and National Park of Palenque
- Pre-Hispanic City of Teotihuacan
- Sian Ka’an
- Historic Town of Guanajuato and Adjacent Mines
- Pre-Hispanic City of Chichen-Itza
- Historic Centre of Morelia
- El Tajin, Pre-Hispanic City
- Historic Centre of Zacatecas
- Rock Paintings of the Sierra de San Francisco
- Whale Sanctuary of El Vizcaino
- Earliest 16th-Century Monasteries on the Slopes of Popocatepetl
- Historic Monuments Zone of Querétaro
- Pre-Hispanic Town of Uxmal
- Hospicio Cabañas, Guadalajara
- Archaeological Zone of Paquimé, Casas Grandes
- Historic Monuments Zone of Tlacotalpan
- Archaeological Monuments Zone of Xochicalco
- Historic Fortified Town of Campeche
- Ancient Maya City and Protected Tropical Forests of Calakmul, Campeche
- Franciscan Missions in the Sierra Gorda of Querétaro
- Luis Barragán House and Studio
- Islands and Protected Areas of the Gulf of California
- Agave Landscape and Ancient Industrial Facilities of Tequila
- Central University City Campus of the Universidad Nacional Autónoma de México (UNAM)
- Monarch Butterfly Biosphere Reserve
- Protective town of San Miguel and the Sanctuary of Jesús Nazareno de Atotonilco
- Camino Real de Tierra Adentro
- Prehistoric Caves of Yagul and Mitla in the Central Valley of Oaxaca
- El Pinacate and Gran Desierto de Altar Biosphere Reserve
- Aqueduct of Padre Tembleque Hydraulic System
- Archipiélago de Revillagigedo
- Tehuacán-Cuicatlán Valley: originary habitat of Mesoamerica
- Nicaragua
- Ruins of León Viejo
- León Cathedral
- Panama
- Fortifications on the Caribbean Side of Panama: Portobelo-San Lorenzo
- Darien National Park
- Talamanca Range-La Amistad Reserves / La Amistad National Park *
- Archaeological Site of Panamá Viejo and Historic District of Panamá
- Coiba National Park and its Special Zone of Marine Protection
- Paraguay
- Jesuit Missions of La Santísima Trinidad de Paraná and Jesús de Tavarangue
- Peru
- City of Cuzco
- Historic Sanctuary of Machu Picchu
- Chavin (Archaeological Site)
- Huascarán National Park #
- Chan Chan Archaeological Zone
- Manú National Park
- Historic Centre of Lima 34
- Río Abiseo National Park
- Lines and Geoglyphs of Nasca and Palpa
- Historical Centre of the City of Arequipa
- Sacred City of Caral-Supe
- Qhapaq Ñan, Andean Road System *
- Chankillo Archaeoastronomical Complex
- Saint Kitts and Nevis
- Brimstone Hill Fortress National Park
- Saint Lucia
- Pitons Management Area
- Suriname
- Central Suriname Nature Reserve
- Historic Inner City of Paramaribo
- Jodensavanne Archaeological Site: Jodensavanne Settlement and Cassipora Creek Cemetery
- Uruguay
- Historic Quarter of the City of Colonia del Sacramento
- Fray Bentos Industrial Landscape
- The work of engineer Eladio Dieste: Church of Atlántida
- Venezuela (Bolivarian Republic of)
- Coro and its Port
- Canaima National Park
- Ciudad Universitaria de Caracas